Embryonic induction is the process by which signals from one tissue change the fate of another adjacent tissue during development. We are interested in identifying the molecular and mechanical cues that control neural crest induction during early development
Cell migration isessential for development and homeostasis. Our aim is to understand the molecular signals and physical events that control cell migration in vivo. We use two of the most migratory cell types during embryo development: the neural crest and macrophages.
Cell differentiation has been mainly studied as the consequence of a genetic cascade activated by molecular signals. We would like to understand how mechanical and molecular signals interplay in controlling fate decision during cell differentiation.
Roberto Mayor
Professor of Developmental and Cellular Neurobiology
Named International Scholar of the Howard Hughes Medical Institute (HHMI), EMBO member and member of the Latin American Academy of Sciences. Editor in Chief of the journals Cells & Development and Gene Expression Patterns and associate editor of many others. Founder and first president elect of the Latin American Society of Developmental Biology (LASDB).
r.mayor@ucl.ac.uk
Lucas Alvizi
Postdoc
Epigentics of neural crest development
l.alvizi@ucl.ac.uk
Jonas Hartmann
Postdoc
Long term EMBO fellowship
Systems microscopy of cell shape and cell fate
jonas.hartmann@ucl.ac.uk
Hoang Anh Le (Anh)
Postdoc
Sir Henry Wellcome Fellowship
Macropinocytosis in cell migration
anh.le@ucl.ac.uk
Amrutha Patkunarajah
Postdoc
Mechano-sensing in neural crest cell migration
a.patkunarajah@ucl.ac.uk
Jorge Diaz
Postdoc
Non-canonical mechanism of neural crest cell migration
jorge.diaz@ucl.ac.uk
Kai Weissenbruch
Postdoc
Intracellular force generation in cell migration and morphogenesis
k.weissenbruch@ucl.ac.uk
Matyas Bubna-Litic
PhD Student
Mechanics guided control of early cell fate decisions
m.bubna-litic@ucl.ac.uk
John Qi
PhD Student
Mechanics of stem cell neural crest
john.qi.19@ucl.ac.uk
Natalia Rendon Serna
PhD Student
natalia.serna.23@ucl.ac.uk
Zhang Yuanjun, PhD student
Adam Shellard, Postdoc
Namid Stillman, Postdoc
Delan Alasaadi, PhD student
Brenda Canales Coutiño, Postdoc
Melisa Turan, PhD student
Oliver Cameron, MRes student
Soraya Villaseca, visiting PhD student
Elias Barriga, EMBO Postdoc
Jaime Espina, visiting PhD student
Nil Ege, Postdoc
Maria Belen Palacio, visiting PhD student
Andras Szabo, Marie Curie Postdoc
Maria Kotini, PhD student
Isabel Bahm, PhD student
Emily Atala, MRes student
Manuela Melchinda, PhD student, Postdoc
Alice Roycroft, PhD student
Alfredo Samsone, Marie Curie Postdoc
Elena Scarpa, PhD student
Sophie Mclachlan, PhD student
Jon Leslie, Postdoc
Marta Caldeira, MRes student
Gabriela Toro, visiting PhD student
Rachel Moore, PhD student
Eric Thevenau, Postdoc
Roger Escofet, PhD student
Mae Woods, PhD student
Isidoro Cobo, PhD student
Ben Steventon, PhD student, Postdoc
Carlos Carmona-Fontaine, PhD student
Mauricio Moreno, Postdoc
Bo Li, PhD student
Sei Kuriyama, Postdoc
Helen Matthews, PhD student
Lorena Marchant, Postdoc
Manuel Aybar, Postdoc
Francisca Ayala, PhD student
Celeste Tribulo, PhD student
Stella Maris Honore, PhD student
Jaime De Calisto, BSc student
Claudio Araya, BSc student
Leo Validivia, BSc student
Sandra Villanueva, PhD student
Alvaro Glavic, PhD student
Carlos Martinez, BSc student
Nestor Guerreo, BSc student
Alejandra Mancilla, Postdoc
Jose Luis Gomez-Skarmeta, Postdoc
Rodrigo Young, BSc student
Pablo Ruiz, BSc student
Claudia Linker, Postdoc
For a full list of publications click here:
Alasaadi DN, Alvizi L, Hartmann J, Stillman N, Moghe P, Hiiragi T, Mayor R. (2024). Competence for neural crest induction is controlled by hydrostatic pressure through Yap. Nature Cell Biology. 26, 530-541
Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R. (2023). Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction.Nature Commun. 14(1):2868. doi: 10.1038/s41467-023-38526-1.
Shellard A, Mayor R. (2021).
Collective durotaxis along a self-generated stiffness gradient in vivo
Nature. 600:690-694
https://doi: 10.1038/s41586-021-04210-x
Canales Coutino, Mayor R. (2021).
The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration
Development. 148, dev200001.
https://doi: 10.1242/dev.200001
Shellard A, Mayor R. (2021)
Durotaxis: The Hard Path from In Vitro to In Vivo.
Dev Cell. 56,227-239.
https://doi.org/10.1016/j.devcel.2020.11.019
Shellard A, Mayor R. (2020).
All Roads Lead to Directional Cell Migration.
Trends Cell Biol. 30, 852-868.
https://doi.org/10.1016/j.tcb.2020.08.002
Barriga EH, Franze K, Charras G, Mayor R (2018).
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.
Nature. 554, 523-527
https://doi.org/10.1038/nature25742
Shellard A, Szabó A, Trepat X, Mayor R. (2018).
Supracellular contraction at the rear of neuralcrest cell groups drives collective chemotaxis.
Science. 362, 339-343
https://doi.org/10.1126/science.aau3301
Stramer B and Mayor R. (2017).
Mechanisms and in vivo functions of contact inhibition of locomotion.
Nat Rev Mol Cell Biol.18, 43-55.
https://doi.org/10.1038/nrm.2016.118
Mayor R, Etienne-Manneville S.(2016).
The front and rear of collective cell migration.
Nat Rev Mol Cell Biol
https://doi.org/10.1038/nrm.2015.14
Scarpa E, Szabó A, Bibonne A, Theveneau E, Parsons M, Mayor R. (2015).
Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces.
Dev Cell. 34, 421-34 [PMC4552721]
https://doi.org/10.1016/j.devcel.2015.06.012
Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, Kabla A, Mayor R. (2014).
In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity.
J Cell Biol. 206, 113-27.[PMC4085712]
https://doi.org/10.1083/jcb.201402093
Theveneau E, Steventon B, Scarpa E, Garcia S, Trepat X, Streit A, Mayor R. (2013).
Chase-and-run between adjacent cell populations promotes directional collective migration.
Nature Cell Biol. 15, 763-72. [PMC4910871]
https://doi.org/10.1038/ncb2772
Carmona-Fontaine C, Matthews HK, Kuriyama S, Moreno M, Dunn GA, Parsons M, Stern CD, Mayor R. (2008). Contact inhibition of locomotion in vivo controls neural crest directional migration.
Nature.456, 957-61. [PMC2635562]
https://doi.org/10.1038/nature07441
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